Cargando…

p300-mediated acetylation of COMMD1 regulates its stability, and the ubiquitylation and nucleolar translocation of the RelA NF-κB subunit

Nucleolar sequestration of the RelA subunit of nuclear factor (NF)-κB is an important mechanism for regulating NF-κB transcriptional activity. Ubiquitylation, facilitated by COMMD1 (also known as MURR1), acts as a crucial nucleolar-targeting signal for RelA, but how this ubiquitylation is regulated,...

Descripción completa

Detalles Bibliográficos
Autores principales:	O'Hara, Andrew, Simpson, James, Morin, Pierre, Loveridge, Carolyn J., Williams, Ann C., Novo, Sonia M., Stark, Lesley A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists 2014
Materias:	Short Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150058/ https://www.ncbi.nlm.nih.gov/pubmed/25074812 http://dx.doi.org/10.1242/jcs.149328

Ejemplares similares

Functional relevance of novel p300-mediated lysine 314 and 315 acetylation of RelA/p65
por: Buerki, Christine, et al.
Publicado: (2008)

Regulation of NF-κB activity by competition between RelA acetylation and ubiquitination
por: Li, Haiying, et al.
Publicado: (2011)

Subinhibitory Concentrations of Bacteriostatic Antibiotics Induce relA-Dependent and relA-Independent Tolerance to β-Lactams
por: Kudrin, Pavel, et al.
Publicado: (2017)

Influence of the relA gene on ribosome frameshifting
por: Masucci, J., et al.
Publicado: (2002)

Identification of genes responsible for RelA-dependent proliferation arrest in human mammary epithelial cells conditionally expressing RelA
por: Kochupurakkal, Bose S., et al.
Publicado: (2015)

NF-κB/Rel Transcription Factors in Pancreatic Cancer: Focusing on RelA, c-Rel, and RelB
por: Kabacaoglu, Derya, et al.
Publicado: (2019)

relA Enhances the Adherence of Enteropathogenic Escherichia coli
por: Spira, Beny, et al.
Publicado: (2014)

relA Inactivation Converts Sulfonamides Into Bactericidal Compounds
por: Si, Lizhen, et al.
Publicado: (2021)

Thr(435) phosphorylation regulates RelA (p65) NF-κB subunit transactivation
por: O'Shea, John M., et al.
Publicado: (2010)

The acetylation of RelA in Lys310 dictates the NF-κB-dependent response in post-ischemic injury
por: Lanzillotta, A, et al.
Publicado: (2010)

The acetylation of RelA in Lys310 dictates the NF-κB-dependent response in post-ischemic injury
Publicado: (2010)

RelA-Induced Interferon Response Negatively Regulates Proliferation
por: Kochupurakkal, Bose S., et al.
Publicado: (2015)

RelA NF-κB subunit activation as a therapeutic target in diffuse large B-cell lymphoma
por: Zhang, Mingzhi, et al.
Publicado: (2016)

Acetylation state of RelA modulated by epigenetic drugs prolongs survival and induces a neuroprotective effect on ALS murine model
por: Schiaffino, Lorenzo, et al.
Publicado: (2018)

The Role of relA and spoT in Yersinia pestis KIM5(+) Pathogenicity
por: Sun, Wei, et al.
Publicado: (2009)

IRF5:RelA Interaction Targets Inflammatory Genes in Macrophages
por: Saliba, David G., et al.
Publicado: (2014)

Ribosome•RelA structures reveal the mechanism of stringent response activation
por: Loveland, Anna B, et al.
Publicado: (2016)

Effects of Human RelA Transgene on Murine Macrophage Inflammatory Responses
por: Papoutsopoulou, Stamatia, et al.
Publicado: (2022)

The NF-κB Subunit RelA/p65 Is Dispensable for Successful Liver Regeneration after Partial Hepatectomy in Mice
por: Ringelhan, Marc, et al.
Publicado: (2012)

Hypoxia induces rapid, STAT3 and ROS dependent, mitochondrial translocation of RelA(p65) and IκBα
por: Ivanova, Iglika G., et al.
Publicado: (2019)

Disabling the Nuclear Translocalization of RelA/NF-κB by a Small Molecule Inhibits Triple-Negative Breast Cancer Growth
por: Kanzaki, Hirotaka, et al.
Publicado: (2021)

Differential RelA- and RelB-dependent gene transcription in LTβR-stimulated mouse embryonic fibroblasts
por: Lovas, Agnes, et al.
Publicado: (2008)

NF-κB Repression by PIAS3 Mediated RelA SUMOylation
por: Liu, Yuangang, et al.
Publicado: (2012)

Biochemical studies on Francisella tularensis RelA in (p)ppGpp biosynthesis
por: Wilkinson, Rachael C., et al.
Publicado: (2015)

RelA Mutant Enterococcus faecium with Multiantibiotic Tolerance Arising in an Immunocompromised Host
por: Honsa, Erin S., et al.
Publicado: (2017)

Molecular mutagenesis of ppGpp: turning a RelA activator into an inhibitor
por: Beljantseva, Jelena, et al.
Publicado: (2017)

Intramolecular Interactions Dominate the Autoregulation of Escherichia coli Stringent Factor RelA
por: Turnbull, Kathryn Jane, et al.
Publicado: (2019)

Escherichia coli RelA Regulation via Its C-Terminal Domain
por: Kaspy, Ilana, et al.
Publicado: (2020)

Identification of a novel TIF-IA–NF-κB nucleolar stress response pathway
por: Chen, Jingyu, et al.
Publicado: (2018)

Stapling proteins in the RELA complex inhibits TNFα-induced nuclear translocation of RELA
por: Kour, Smit, et al.
Publicado: (2021)

relA over-expression reduces tumorigenicity and activates apoptosis in human cancer cells
por: Ricca, A, et al.
Publicado: (2001)

Deletion of relA abrogates the capacity of Mycobacterium avium paratuberculosis to establish an infection in calves
por: Park, Kun Taek, et al.
Publicado: (2014)

A Comparative Proteome Analysis of Escherichia coli ΔrelA Mutant Cells
por: Carneiro, Sónia, et al.
Publicado: (2016)

The ribosomal A-site finger is crucial for binding and activation of the stringent factor RelA
por: Kudrin, Pavel, et al.
Publicado: (2018)

Deubiquitinylase USP47 Promotes RelA Phosphorylation and Survival in Gastric Cancer Cells
por: Naghavi, Lara, et al.
Publicado: (2018)

Identification of a Selective RelA Inhibitor Based on DSE-FRET Screening Methods
por: Shiroma, Yoshitomo, et al.
Publicado: (2020)

NirD curtails the stringent response by inhibiting RelA activity in Escherichia coli
por: Léger, Loïc, et al.
Publicado: (2021)

Starvation sensing by mycobacterial RelA/SpoT homologue through constitutive surveillance of translation
por: Li, Yunlong, et al.
Publicado: (2023)

A Critical Role for the RelA Subunit of Nuclear Factor κB in Regulation of Multiple Immune-response Genes and in Fas-induced Cell Death
por: Ouaaz, Fateh, et al.
Publicado: (1999)

Cyclophilin A (CypA) Interacts with NF-κB Subunit, p65/RelA, and Contributes to NF-κB Activation Signaling
por: Sun, Shan, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_f564213eei003te6pnea9h394a