Eukaryotic translation initiation factor eIF5 promotes the accuracy of start codon recognition by regulating P(i) release and conformational transitions of the preinitiation complex

Mostrar otras versiones (1)

eIF5 is the GTPase activating protein (GAP) for the eIF2·GTP·Met-tRNA(i)(Met) ternary complex with a critical role in initiation codon selection. Previous work suggested that the eIF5 mutation G31R/SUI5 elevates initiation at UUG codons by increasing GAP function. Subsequent work implicated eIF5 in...

Descripción completa

Detalles Bibliográficos
Autores principales: Saini, Adesh K., Nanda, Jagpreet S., Martin-Marcos, Pilar, Dong, Jinsheng, Zhang, Fan, Bhardwaj, Monika, Lorsch, Jon R., Hinnebusch, Alan G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150770/
https://www.ncbi.nlm.nih.gov/pubmed/25114053
http://dx.doi.org/10.1093/nar/gku653

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150770/
https://www.ncbi.nlm.nih.gov/pubmed/25114053
http://dx.doi.org/10.1093/nar/gku653

Ejemplares similares