Eukaryotic translation initiation factor eIF5 promotes the accuracy of start codon recognition by regulating P(i) release and conformational transitions of the preinitiation complex

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eIF5 is the GTPase activating protein (GAP) for the eIF2·GTP·Met-tRNA(i)(Met) ternary complex with a critical role in initiation codon selection. Previous work suggested that the eIF5 mutation G31R/SUI5 elevates initiation at UUG codons by increasing GAP function. Subsequent work implicated eIF5 in...

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Detalles Bibliográficos
Autores principales: Saini, Adesh K., Nanda, Jagpreet S., Martin-Marcos, Pilar, Dong, Jinsheng, Zhang, Fan, Bhardwaj, Monika, Lorsch, Jon R., Hinnebusch, Alan G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150770/
https://www.ncbi.nlm.nih.gov/pubmed/25114053
http://dx.doi.org/10.1093/nar/gku653
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