High-throughput mutagenesis reveals functional determinants for DNA targeting by activation-induced deaminase

Antibody maturation is a critical immune process governed by the enzyme activation-induced deaminase (AID), a member of the AID/APOBEC DNA deaminase family. AID/APOBEC deaminases preferentially target cytosine within distinct preferred sequence motifs in DNA, with specificity largely conferred by a...

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Detalles Bibliográficos
Autores principales: Gajula, Kiran S., Huwe, Peter J., Mo, Charlie Y., Crawford, Daniel J., Stivers, James T., Radhakrishnan, Ravi, Kohli, Rahul M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150791/
https://www.ncbi.nlm.nih.gov/pubmed/25064858
http://dx.doi.org/10.1093/nar/gku689

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150791/
https://www.ncbi.nlm.nih.gov/pubmed/25064858
http://dx.doi.org/10.1093/nar/gku689

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