Interaction Between Domperidone and Ketoconazole: Toward Prediction of Consequent QTc Prolongation Using Purely In Vitro Information

We aimed to investigate the application of combined mechanistic pharmacokinetic (PK) and pharmacodynamic (PD) modeling and simulation in predicting the domperidone (DOM) triggered pseudo-electrocardiogram modification in the presence of a CYP3A inhibitor, ketoconazole (KETO), using in vitro–in vivo...

Descripción completa

Detalles Bibliográficos
Autores principales: Mishra, H, Polak, S, Jamei, M, Rostami-Hodjegan, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150924/
https://www.ncbi.nlm.nih.gov/pubmed/25116274
http://dx.doi.org/10.1038/psp.2014.26

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150924/
https://www.ncbi.nlm.nih.gov/pubmed/25116274
http://dx.doi.org/10.1038/psp.2014.26

Ejemplares similares