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Predicting QTc Prolongation in Man From Only In Vitro Data
Mishra et al.(1) in their article “Interaction between domperidone and ketoconazole: toward prediction of consequent QTc prolongation using purely in vitro information” describe the use of physiologically based pharmacokinetic (PBPK) modeling and pharmacodynamic models of cardiac repolarization to p...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150928/ https://www.ncbi.nlm.nih.gov/pubmed/25141222 http://dx.doi.org/10.1038/psp.2014.33 |