Context-dependent signal integration by the GLI code: The oncogenic load, pathways, modifiers and implications for cancer therapy

Canonical Hedgehog (HH) signaling leads to the regulation of the GLI code: the sum of all positive and negative functions of all GLI proteins. In humans, the three GLI factors encode context-dependent activities with GLI1 being mostly an activator and GLI3 often a repressor. Modulation of GLI activi...

Descripción completa

Detalles Bibliográficos
Autores principales: Aberger, Fritz, Ruiz i Altaba, Ariel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151135/
https://www.ncbi.nlm.nih.gov/pubmed/24852887
http://dx.doi.org/10.1016/j.semcdb.2014.05.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151135/
https://www.ncbi.nlm.nih.gov/pubmed/24852887
http://dx.doi.org/10.1016/j.semcdb.2014.05.003

Ejemplares similares