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Context-dependent signal integration by the GLI code: The oncogenic load, pathways, modifiers and implications for cancer therapy
Canonical Hedgehog (HH) signaling leads to the regulation of the GLI code: the sum of all positive and negative functions of all GLI proteins. In humans, the three GLI factors encode context-dependent activities with GLI1 being mostly an activator and GLI3 often a repressor. Modulation of GLI activi...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Academic Press
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151135/ https://www.ncbi.nlm.nih.gov/pubmed/24852887 http://dx.doi.org/10.1016/j.semcdb.2014.05.003 |