Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin

To minimize oxidative damage to the cell, malfunctioning mitochondria need to be removed by mitophagy. In neuronal axons, mitochondrial damage may occur in distal regions, far from the soma where most lysosomal degradation is thought to occur. In this paper, we report that PINK1 and Parkin, two Park...

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Detalles Bibliográficos
Autores principales: Ashrafi, Ghazaleh, Schlehe, Julia S., LaVoie, Matthew J., Schwarz, Thomas L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151150/
https://www.ncbi.nlm.nih.gov/pubmed/25154397
http://dx.doi.org/10.1083/jcb.201401070

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151150/
https://www.ncbi.nlm.nih.gov/pubmed/25154397
http://dx.doi.org/10.1083/jcb.201401070

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