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Early identification of hERG liability in drug discovery programs by automated patch clamp

Blockade of the cardiac ion channel coded by human ether-à-gogo-related gene (hERG) can lead to cardiac arrhythmia, which has become a major concern in drug discovery and development. Automated electrophysiological patch clamp allows assessment of hERG channel effects early in drug development to ai...

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Detalles Bibliográficos
Autores principales: Danker, Timm, Möller, Clemens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151236/
https://www.ncbi.nlm.nih.gov/pubmed/25228880
http://dx.doi.org/10.3389/fphar.2014.00203