Cargando…
The histamine H(4) receptor mediates inflammation and Th17 responses in preclinical models of arthritis
OBJECTIVE: The histamine H(4) receptor (H(4)R) has been shown to drive inflammatory responses in models of asthma, colitis and dermatitis, and in these models it appears to affect both innate and adaptive immune responses. In this study, we used both H(4)R-deficient mice and a specific H(4)R antagon...
Autores principales: | Cowden, Jeffery M, Yu, Fuqu, Banie, Homayon, Farahani, Mandana, Ling, Ping, Nguyen, Steven, Riley, Jason P, Zhang, Mai, Zhu, Jian, Dunford, Paul J, Thurmond, Robin L |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151522/ https://www.ncbi.nlm.nih.gov/pubmed/24126456 http://dx.doi.org/10.1136/annrheumdis-2013-203832 |
Ejemplares similares
-
Histamine H4 receptor antagonism diminishes existing airway inflammation and dysfunction via modulation of Th2 cytokines
por: Cowden, Jeffery M, et al.
Publicado: (2010) -
Antagonism of the histamine H(4) receptor reduces LPS-induced TNF production in vivo
por: Cowden, Jeffery M., et al.
Publicado: (2013) -
Preclinical characterisation of the GM-CSF receptor as a therapeutic target in rheumatoid arthritis
por: Greven, D E A, et al.
Publicado: (2015) -
Exacerbated inflammatory arthritis in response to hyperactive gp130 signalling is independent of IL-17A
por: Jones, G W, et al.
Publicado: (2013) -
MICL controls inflammation in rheumatoid arthritis
por: Redelinghuys, Pierre, et al.
Publicado: (2016)