Drug Resistance Conferred by Mutations Outside the Active Site through Alterations in the Dynamic and Structural Ensemble of HIV-1 Protease

[Image: see text] HIV-1 protease inhibitors are part of the highly active antiretroviral therapy effectively used in the treatment of HIV infection and AIDS. Darunavir (DRV) is the most potent of these inhibitors, soliciting drug resistance only when a complex combination of mutations occur both ins...

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Detalles Bibliográficos
Autores principales: Ragland, Debra A., Nalivaika, Ellen A., Nalam, Madhavi N. L., Prachanronarong, Kristina L., Cao, Hong, Bandaranayake, Rajintha M., Cai, Yufeng, Kurt-Yilmaz, Nese, Schiffer, Celia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151706/
https://www.ncbi.nlm.nih.gov/pubmed/25091085
http://dx.doi.org/10.1021/ja504096m

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151706/
https://www.ncbi.nlm.nih.gov/pubmed/25091085
http://dx.doi.org/10.1021/ja504096m

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