Involvement of p53 Mutation and Mismatch Repair Proteins Dysregulation in NNK-Induced Malignant Transformation of Human Bronchial Epithelial Cells

Genome integrity is essential for normal cellular functions and cell survival. Its instability can cause genetic aberrations and is considered as a hallmark of most cancers. To investigate the carcinogenesis process induced by tobacco-specific carcinogen NNK, we studied the dynamic changes of two im...

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Detalles Bibliográficos
Autores principales: Shen, Ying, Zhang, Shuilian, Huang, Xiaobin, Chen, Kailin, Shen, Jing, Wang, Zhengyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151862/
https://www.ncbi.nlm.nih.gov/pubmed/25215298
http://dx.doi.org/10.1155/2014/920275

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151862/
https://www.ncbi.nlm.nih.gov/pubmed/25215298
http://dx.doi.org/10.1155/2014/920275

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