Cargando…

Involvement of p53 Mutation and Mismatch Repair Proteins Dysregulation in NNK-Induced Malignant Transformation of Human Bronchial Epithelial Cells

Genome integrity is essential for normal cellular functions and cell survival. Its instability can cause genetic aberrations and is considered as a hallmark of most cancers. To investigate the carcinogenesis process induced by tobacco-specific carcinogen NNK, we studied the dynamic changes of two im...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shen, Ying, Zhang, Shuilian, Huang, Xiaobin, Chen, Kailin, Shen, Jing, Wang, Zhengyang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151862/ https://www.ncbi.nlm.nih.gov/pubmed/25215298 http://dx.doi.org/10.1155/2014/920275

Ejemplares similares

XB130 translocation to microfilamentous structures mediates NNK-induced migration of human bronchial epithelial cells
por: Wu, Qifei, et al.
Publicado: (2015)

Molecular Mechanisms of Malignant Transformation by Low Dose Cadmium in Normal Human Bronchial Epithelial Cells
por: Cartularo, Laura, et al.
Publicado: (2016)

The Effect of NNK, A Tobacco Smoke Carcinogen, on the miRNA and Mismatch DNA Repair Expression Profiles in Lung and Head and Neck Squamous Cancer Cells
por: Doukas, Sotirios G., et al.
Publicado: (2020)

Malignant transformation of immortalized human bronchial epithelial cells by asbestos fibers.
por: Hei, T K, et al.
Publicado: (1997)

Molecular interaction analysis of cigarette smoke carcinogens NNK and NNAL with enzymes involved in DNA repair pathways: An in silico approach
por: Jamal, Qazi Mohd Sajid, et al.
Publicado: (2012)

The Role of Nitrosamine (NNK) in Breast Cancer Carcinogenesis
por: Gankhuyag, Nomundelger, et al.
Publicado: (2017)

MicroRNAs-mRNAs Expression Profile and Their Potential Role in Malignant Transformation of Human Bronchial Epithelial Cells Induced by Cadmium
por: Liu, Qun, et al.
Publicado: (2015)

The Effect of Tobacco Smoke N-Nitrosamines, NNK and NDEA, and Nicotine, on DNA Mismatch Repair Mechanism and miRNA Markers, in Hypopharyngeal Squamous Cell Carcinoma: An In Vivo Model and Clinical Evidence
por: Doukas, Sotirios G., et al.
Publicado: (2022)

Mechanisms of Cancer Induction by Tobacco-Specific NNK and NNN
por: Xue, Jiaping, et al.
Publicado: (2014)

The permissive role of TCTP in PM(2.5)/NNK-induced epithelial–mesenchymal transition in lung cells
por: Liu, Li-Zhong, et al.
Publicado: (2020)

HER2 Overexpression and Mismatch Repair Deficiency are Correlated with Malignancy in Colorectal Cancer
por: Luo, Hai, et al.
Publicado: (2021)

NNK-Induced Lung Tumors: A Review of Animal Model
por: Zheng, Hua-Chuan, et al.
Publicado: (2011)

miR675 Accelerates Malignant Transformation of Mesenchymal Stem Cells by Blocking DNA Mismatch Repair
por: Lu, Yanan, et al.
Publicado: (2018)

Cadmium Induced Cell Apoptosis, DNA Damage, Decreased DNA Repair Capacity, and Genomic Instability during Malignant Transformation of Human Bronchial Epithelial Cells
por: Zhou, Zhiheng, et al.
Publicado: (2013)

EMT and Stem Cell-Like Properties Associated with HIF-2α Are Involved in Arsenite-Induced Transformation of Human Bronchial Epithelial Cells
por: Xu, Yuan, et al.
Publicado: (2012)

Integrated Analysis of Mismatch Repair System in Malignant Astrocytomas
por: Rodríguez-Hernández, Irene, et al.
Publicado: (2013)

Retraction: Cadmium Induced Cell Apoptosis, DNA Damage, Decreased DNA Repair Capacity, and Genomic Instability during Malignant Transformation of Human Bronchial Epithelial Cells
por: Zhou, Zhiheng, et al.
Publicado: (2014)

LncRNAs expression signatures of cadmium-induced malignant transformation of human bronchial epithelial cells revealed by microarray
por: Zhou, Zhi-heng, et al.
Publicado: (2013)

Upregulation of SQSTM1/p62 contributes to nickel-induced malignant transformation of human bronchial epithelial cells
por: Huang, Haishan, et al.
Publicado: (2016)

Universal Screening of Gastrointestinal Malignancies for Mismatch Repair Deficiency at Stanford
por: Abrha, Aser, et al.
Publicado: (2020)

Cr(VI)-induced malignant transformation of a bronchial epithelial cell line association with altered mitochondria and bioenergetic phenotypes
por: Sampaio, Ana, et al.
Publicado: (2010)

Transformation of human bronchial epithelial cells alters responsiveness to inflammatory cytokines
por: Loewen, Gregory M, et al.
Publicado: (2005)

Involvement of Nucleotide Excision and Mismatch Repair Mechanisms in Double Strand Break Repair
por: Zhang, Ye, et al.
Publicado: (2009)

Dysregulated Arginine Metabolism in Young Patients with Chronic Persistent Asthma and in Human Bronchial Epithelial Cells
por: Zhou, Bo, et al.
Publicado: (2021)

Involvement of the β Clamp in Methyl-directed Mismatch Repair in Vitro
por: Pluciennik, Anna, et al.
Publicado: (2009)

Involvement of MBD4 inactivation in mismatch repair-deficient tumorigenesis
por: Tricarico, Rossella, et al.
Publicado: (2015)

IKBKE Upregulation is Positively Associated with Squamous Cell Carcinoma of the Lung In Vivo and Malignant Transformation of Human Bronchial Epithelial Cells In Vitro
por: Li, Wei, et al.
Publicado: (2015)

MicroRNA and mRNA Interaction Network Regulates the Malignant Transformation of Human Bronchial Epithelial Cells Induced by Cigarette Smoke
por: Wang, Jin, et al.
Publicado: (2019)

Relationship of microsatellite instability to mismatch repair deficiency in malignant tumors of dogs
por: Inanaga, Sakuya, et al.
Publicado: (2022)

miR-124 Inhibits Lung Tumorigenesis Induced by K-ras Mutation and NNK
por: Jin, Hua, et al.
Publicado: (2017)

Targeting CD36 determines nicotine derivative NNK-induced lung adenocarcinoma carcinogenesis
por: Li, Ming-Yue, et al.
Publicado: (2023)

A MicroRNA Network Dysregulated in Asthma Controls IL-6 Production in Bronchial Epithelial Cells
por: Martinez-Nunez, Rocio T., et al.
Publicado: (2014)

Dysregulated mitochondrial metabolism upon cigarette smoke exposure in various human bronchial epithelial cell models
por: Tulen, Christy B. M., et al.
Publicado: (2022)

Altered microRNA expression profile during epithelial wound repair in bronchial epithelial cells
por: Szczepankiewicz, Aleksandra, et al.
Publicado: (2013)

Deficiency of CCAAT/enhancer binding protein family DNA binding prevents malignant conversion of adenoma to carcinoma in NNK-induced lung carcinogenesis in the mouse
por: Kimura, Shioko, et al.
Publicado: (2012)

Immunohistochemical evaluation of mismatch repair proteins and p53 expression in extrauterine carcinosarcoma/sarcomatoid carcinoma
por: Kunc, Michał, et al.
Publicado: (2020)

Early and delayed intervention with Rapamycin prevents NNK-induced lung adenocarcinoma in A/J mice
por: PATLOLLA, JAGAN M.R., et al.
Publicado: (2015)

NNK, a Tobacco-Specific Carcinogen, Inhibits the Expression of Lysyl Oxidase, a Tumor Suppressor
por: Cheng, Guang, et al.
Publicado: (2014)

uPAR regulates bronchial epithelial repair in vitro and is elevated in asthmatic epithelium
por: Stewart, Ceri E, et al.
Publicado: (2011)

Mismatch repair deficiencies transforming stem cells into cancer stem cells and therapeutic implications
por: Vaish, Minal
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_buuh1tip77rk33hrvc0rtu88us