Application of Multi-Objective Optimization to Pooled Experiments of Next Generation Sequencing for Detection of Rare Mutations

In this paper we propose some mathematical models to plan a Next Generation Sequencing experiment to detect rare mutations in pools of patients. A mathematical optimization problem is formulated for optimal pooling, with respect to minimization of the experiment cost. Then, two different strategies...

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Detalles Bibliográficos
Autores principales: Žilinskas, Julius, Lančinskas, Algirdas, Guarracino, Mario Rosario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4152218/
https://www.ncbi.nlm.nih.gov/pubmed/25181462
http://dx.doi.org/10.1371/journal.pone.0104992

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4152218/
https://www.ncbi.nlm.nih.gov/pubmed/25181462
http://dx.doi.org/10.1371/journal.pone.0104992

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