The importance of helix P1 stability for structural pre-organization and ligand binding affinity of the adenine riboswitch aptamer domain

We report here an in-depth characterization of the aptamer domain of the transcriptional adenine-sensing riboswitch (pbuE) by NMR and fluorescence spectroscopy. By NMR studies, the structure of two aptamer sequences with different lengths of the helix P1, the central element involved in riboswitch c...

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Detalles Bibliográficos
Autores principales: Nozinovic, Senada, Reining, Anke, Kim, Yong-Boum, Noeske, Jonas, Schlepckow, Kai, Wöhnert, Jens, Schwalbe, Harald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4152369/
https://www.ncbi.nlm.nih.gov/pubmed/24921630
http://dx.doi.org/10.4161/rna.29439

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4152369/
https://www.ncbi.nlm.nih.gov/pubmed/24921630
http://dx.doi.org/10.4161/rna.29439

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