Tandospirone, a 5-HT(1A) partial agonist, ameliorates aberrant lactate production in the prefrontal cortex of rats exposed to blockade of N-methy-D-aspartate receptors; Toward the therapeutics of cognitive impairment of schizophrenia

Rationale: Augmentation therapy with serotonin-1A (5-HT(1A)) receptor partial agonists has been suggested to improve cognitive impairment in patients with schizophrenia. Decreased activity of prefrontal cortex may provide a basis for cognitive deficits of the disease. Lactate plays a significant rol...

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Detalles Bibliográficos
Autores principales: Uehara, Takashi, Matsuoka, Tadasu, Sumiyoshi, Tomiki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153291/
https://www.ncbi.nlm.nih.gov/pubmed/25232308
http://dx.doi.org/10.3389/fnbeh.2014.00291

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153291/
https://www.ncbi.nlm.nih.gov/pubmed/25232308
http://dx.doi.org/10.3389/fnbeh.2014.00291

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