Inhibiting CCN1 blocks AML cell growth by disrupting the MEK/ERK pathway

BACKGROUND: CCN1 plays distinct roles in various tumor types, but little is known regarding the role of CCN1 in leukemia. METHODS: We analyzed CCN1 protein expression in leukemia cell lines and in AML bone marrow samples. We also evaluated the effects of antibody- or siRNA-mediated inhibition of CCN...

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Detalles Bibliográficos
Autores principales: Niu, Chang-Chun, Zhao, Chen, Yang, Zhong, Zhang, Xiao-Li, Pan, Jing, Si, Wei-Ke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153307/
https://www.ncbi.nlm.nih.gov/pubmed/25187756
http://dx.doi.org/10.1186/s12935-014-0074-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153307/
https://www.ncbi.nlm.nih.gov/pubmed/25187756
http://dx.doi.org/10.1186/s12935-014-0074-z

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