Cargando…

Inhibiting CCN1 blocks AML cell growth by disrupting the MEK/ERK pathway

BACKGROUND: CCN1 plays distinct roles in various tumor types, but little is known regarding the role of CCN1 in leukemia. METHODS: We analyzed CCN1 protein expression in leukemia cell lines and in AML bone marrow samples. We also evaluated the effects of antibody- or siRNA-mediated inhibition of CCN...

Descripción completa

Detalles Bibliográficos
Autores principales:	Niu, Chang-Chun, Zhao, Chen, Yang, Zhong, Zhang, Xiao-Li, Pan, Jing, Si, Wei-Ke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153307/ https://www.ncbi.nlm.nih.gov/pubmed/25187756 http://dx.doi.org/10.1186/s12935-014-0074-z

Ejemplares similares

Epigallocatechin-3-gallate inhibits the growth and increases the apoptosis of human thyroid carcinoma cells through suppression of EGFR/RAS/RAF/MEK/ERK signaling pathway
por: Wu, Dongdong, et al.
Publicado: (2019)

Benzimidazoisoquinoline derivatives inhibit glioblastoma cell proliferation through down-regulating Raf/MEK/ERK and PI3K/AKT pathways
por: Zhang, Ya-Jun, et al.
Publicado: (2018)

Inhibition of the PI3K but not the MEK/ERK pathway sensitizes human glioma cells to alkylating drugs
por: Haas, Bodo, et al.
Publicado: (2018)

Down-regulation of TRIB3 inhibits the progression of ovarian cancer via MEK/ERK signaling pathway
por: Wang, Shuang, et al.
Publicado: (2020)

Norcantharidin induces growth inhibition and apoptosis of glioma cells by blocking the Raf/MEK/ERK pathway
por: Zheng, Jie, et al.
Publicado: (2014)

MiR-155-5p suppresses SOX1 to promote proliferation of cholangiocarcinoma via RAF/MEK/ERK pathway
por: Wang, Da, et al.
Publicado: (2021)

UBTF facilitates melanoma progression via modulating MEK1/2-ERK1/2 signalling pathways by promoting GIT1 transcription
por: Zhang, Jian, et al.
Publicado: (2021)

Overexpression of microRNA-29b inhibits epithelial-mesenchymal transition and angiogenesis of colorectal cancer through the ETV4/ERK/EGFR axis
por: Leng, Yin, et al.
Publicado: (2021)

MEK inhibition induced downregulation of MRP1 and MRP3 expression in experimental hepatocellular carcinoma
por: Lin, Shibo, et al.
Publicado: (2013)

Yin/Yang expression of CCN family members: Transforming growth factor beta 1, via ALK5/FAK/MEK, induces CCN1 and CCN2, yet suppresses CCN3, expression in human dermal fibroblasts
por: Peidl, Alexander, et al.
Publicado: (2019)

Circ_0032821 acts as an oncogene in cell proliferation, metastasis and autophagy in human gastric cancer cells in vitro and in vivo through activating MEK1/ERK1/2 signaling pathway
por: Jiang, Yuanyuan, et al.
Publicado: (2020)

hsa-mir-30c promotes the invasive phenotype of metastatic breast cancer cells by targeting NOV/CCN3
por: Dobson, Jason R, et al.
Publicado: (2014)

Direct Targeting of the Raf-MEK-ERK Signaling Cascade Inhibits Neuroblastoma Growth
por: Chilamakuri, Rameswari, et al.
Publicado: (2022)

KRAS acting through ERK signaling stabilizes PD-L1 via inhibiting autophagy pathway in intrahepatic cholangiocarcinoma
por: Gao, Zheng, et al.
Publicado: (2022)

Growth Inhibitory Signaling of the Raf/MEK/ERK Pathway
por: Wu, Pui-Kei, et al.
Publicado: (2020)

Macrophage polarization-associated lnc-Ma301 interacts with caprin-1 to inhibit hepatocellular carcinoma metastasis through the Akt/Erk1 pathway
por: Luo, Hong-Lin, et al.
Publicado: (2021)

Tanshinone IIA regulates human AML cell proliferation, cell cycle, and apoptosis through miR-497-5p/AKT3 axis
por: Nie, Zi-Yuan, et al.
Publicado: (2020)

Praja2 suppresses the growth of gastric cancer by ubiquitylation of KSR1 and inhibiting MEK-ERK signal pathways
por: Zhao, Zhiwei, et al.
Publicado: (2021)

CCN1/Cyr61 enhances the function of hepatic stellate cells in promoting the progression of hepatocellular carcinoma
por: Li, Zhi-Qiang, et al.
Publicado: (2018)

Clinical and laboratory features of seven patients with acute myeloid leukemia (AML)-M2/M3 and elevated myeloblasts and abnormal promyelocytes
por: He, GanLin, et al.
Publicado: (2014)

PLX8394, a RAF inhibitor, inhibits enterovirus 71 replication by blocking RAF/MEK/ERK signaling
por: Wu, Chengyuan, et al.
Publicado: (2023)

Crocetin protects against cardiac hypertrophy by blocking MEK-ERK1/2 signalling pathway
por: Cai, Jun, et al.
Publicado: (2010)

Crocetin protects against cardiac hypertrophy by blocking MEK-ERK1/2 signalling pathway
por: Cai, Jun, et al.
Publicado: (2009)

IGHG1 Regulates Prostate Cancer Growth via the MEK/ERK/c-Myc Pathway
por: Chu, Jing, et al.
Publicado: (2019)

Vitamin K1 enhances sorafenib-induced growth inhibition and apoptosis of human malignant glioma cells by blocking the Raf/MEK/ERK pathway
por: Du, Wei, et al.
Publicado: (2012)

CLDN2 inhibits the metastasis of osteosarcoma cells via down-regulating the afadin/ERK signaling pathway
por: Zhang, Xiaowei, et al.
Publicado: (2018)

The implications of women’s activity limitations and role disruptions during breast cancer survivorship
por: Keesing, Sharon, et al.
Publicado: (2018)

Changes in the MALT1-A20-NF-κB expression pattern may be related to T cell dysfunction in AML
por: Shi, Li, et al.
Publicado: (2013)

BRAF/MEK inhibitors promote CD47 expression that is reversible by ERK inhibition in melanoma
por: Liu, Fen, et al.
Publicado: (2017)

CircNFIB inhibits tumor growth and metastasis through suppressing MEK1/ERK signaling in intrahepatic cholangiocarcinoma
por: Du, Jinpeng, et al.
Publicado: (2022)

Blocking ERK1/2 signaling impairs TGF-β1 tumor promoting function but enhances its tumor suppressing role in intrahepatic cholangiocarcinoma cells
por: Sritananuwat, Phaijit, et al.
Publicado: (2017)

Inhibition of the angiogenesis and growth of Aloin in human colorectal cancer in vitro and in vivo
por: Pan, Qin, et al.
Publicado: (2013)

The long non-coding RNA AK001796 contributes to tumor growth via regulating expression of p53 in esophageal squamous cell carcinoma
por: Liu, Bin, et al.
Publicado: (2018)

Berberine inhibits enterovirus 71 replication by downregulating the MEK/ERK signaling pathway and autophagy
por: Wang, Huiqiang, et al.
Publicado: (2017)

Mesenchymal stem cells derived from iPSCs expressing interleukin-24 inhibit the growth of melanoma in the tumor-bearing mouse model
por: Wu, Zheng, et al.
Publicado: (2020)

The Extract of Rhodobacter sphaeroides Inhibits Melanogenesis through the MEK/ERK Signaling Pathway
por: Liu, Wen-Sheng, et al.
Publicado: (2013)

Yin and Yang: CCN3 inhibits the pro-fibrotic effects of CCN2
por: Leask, Andrew
Publicado: (2009)

Decreased SATB1 expression promotes AML cell proliferation through NF-κB activation
por: Luo, Xiaodan, et al.
Publicado: (2019)

Markers of MEK inhibitor resistance in low-grade serous ovarian cancer: EGFR is a potential therapeutic target
por: Fernandez, Marta Llaurado, et al.
Publicado: (2019)

Correction: CircNFIB inhibits tumor growth and metastasis through suppressing MEK1/ERK signaling in intrahepatic cholangiocarcinoma
por: Du, Jinpeng, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_e2dv0vi04lk9l3l92dfakq91s2