Development of a Physiologically Based Model to Describe the Pharmacokinetics of Methylphenidate in Juvenile and Adult Humans and Nonhuman Primates

The widespread usage of methylphenidate (MPH) in the pediatric population has received considerable attention due to its potential effect on child development. For the first time a physiologically based pharmacokinetic (PBPK) model has been developed in juvenile and adult humans and nonhuman primate...

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Detalles Bibliográficos
Autores principales: Yang, Xiaoxia, Morris, Suzanne M., Gearhart, Jeffery M., Ruark, Christopher D., Paule, Merle G., Slikker, William, Mattison, Donald R., Vitiello, Benedetto, Twaddle, Nathan C., Doerge, Daniel R., Young, John F., Fisher, Jeffrey W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153582/
https://www.ncbi.nlm.nih.gov/pubmed/25184666
http://dx.doi.org/10.1371/journal.pone.0106101

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153582/
https://www.ncbi.nlm.nih.gov/pubmed/25184666
http://dx.doi.org/10.1371/journal.pone.0106101

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