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Development of a Physiologically Based Model to Describe the Pharmacokinetics of Methylphenidate in Juvenile and Adult Humans and Nonhuman Primates
The widespread usage of methylphenidate (MPH) in the pediatric population has received considerable attention due to its potential effect on child development. For the first time a physiologically based pharmacokinetic (PBPK) model has been developed in juvenile and adult humans and nonhuman primate...
Autores principales: | Yang, Xiaoxia, Morris, Suzanne M., Gearhart, Jeffery M., Ruark, Christopher D., Paule, Merle G., Slikker, William, Mattison, Donald R., Vitiello, Benedetto, Twaddle, Nathan C., Doerge, Daniel R., Young, John F., Fisher, Jeffrey W. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153582/ https://www.ncbi.nlm.nih.gov/pubmed/25184666 http://dx.doi.org/10.1371/journal.pone.0106101 |
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