Phosphoproteomics-Mediated Identification of Fer Kinase as a Target of Mutant Shp2 in Noonan and LEOPARD Syndrome

Noonan syndrome (NS) and LEOPARD syndrome (LS) cause congenital afflictions such as short stature, hypertelorism and heart defects. More than 50% of NS and almost all of LS cases are caused by activating and inactivating mutations of the phosphatase Shp2, respectively. How these biochemically opposi...

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Detalles Bibliográficos
Autores principales: Paardekooper Overman, Jeroen, Preisinger, Christian, Prummel, Karin, Bonetti, Monica, Giansanti, Piero, Heck, Albert, den Hertog, Jeroen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153654/
https://www.ncbi.nlm.nih.gov/pubmed/25184253
http://dx.doi.org/10.1371/journal.pone.0106682

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153654/
https://www.ncbi.nlm.nih.gov/pubmed/25184253
http://dx.doi.org/10.1371/journal.pone.0106682

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