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Proliferating Cell Nuclear Antigen Binds DNA Polymerase-β and Mediates 1-Methyl-4-Phenylpyridinium-Induced Neuronal Death
The mechanisms leading to dopaminergic neuronal loss in the substantia nigra of patients with Parkinson disease (PD) remain poorly understood. We recently reported that aberrant DNA replication mediated by DNA polymerase-β (DNA pol-β) plays a causal role in the death of postmitotic neurons in an in...
Autores principales: | Zhang, Zhentao, Zhang, Zhaohui, Wang, Hongcai, Zhang, Guoxin, Hu, Dan, Xiong, Jing, Xiong, Nian, Wang, Tao, Cao, Xuebing, Mao, Ling |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153671/ https://www.ncbi.nlm.nih.gov/pubmed/25184665 http://dx.doi.org/10.1371/journal.pone.0106669 |
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