Down-regulation of argininosuccinate synthetase is associated with cisplatin resistance in hepatocellular carcinoma cell lines: implications for PEGylated arginine deiminase combination therapy

BACKGROUND: Many advanced human tumors, including hepatocellular carcinomas (HCC) are auxotrophic for arginine due to down-regulation of argininosuccinate synthetase (ASS1), the rate-limiting enzyme in arginine synthesis. The arginine-lowering agent PEGylated arginine deiminase (ADI-PEG 20) has show...

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Detalles Bibliográficos
Autores principales: McAlpine, Jennifer A, Lu, Hsin-Tze, Wu, Katherine C, Knowles, Susan K, Thomson, James A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153943/
https://www.ncbi.nlm.nih.gov/pubmed/25164070
http://dx.doi.org/10.1186/1471-2407-14-621

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153943/
https://www.ncbi.nlm.nih.gov/pubmed/25164070
http://dx.doi.org/10.1186/1471-2407-14-621

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