Improved Utilization of ADAS-Cog Assessment Data Through Item Response Theory Based Pharmacometric Modeling

PURPOSE: This work investigates improved utilization of ADAS-cog data (the primary outcome in Alzheimer’s disease (AD) trials of mild and moderate AD) by combining pharmacometric modeling and item response theory (IRT). METHODS: A baseline IRT model characterizing the ADAS-cog was built based on dat...

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Detalles Bibliográficos
Autores principales: Ueckert, Sebastian, Plan, Elodie L., Ito, Kaori, Karlsson, Mats O., Corrigan, Brian, Hooker, Andrew C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153970/
https://www.ncbi.nlm.nih.gov/pubmed/24595495
http://dx.doi.org/10.1007/s11095-014-1315-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153970/
https://www.ncbi.nlm.nih.gov/pubmed/24595495
http://dx.doi.org/10.1007/s11095-014-1315-5

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