Cargando…
Improved Utilization of ADAS-Cog Assessment Data Through Item Response Theory Based Pharmacometric Modeling
PURPOSE: This work investigates improved utilization of ADAS-cog data (the primary outcome in Alzheimer’s disease (AD) trials of mild and moderate AD) by combining pharmacometric modeling and item response theory (IRT). METHODS: A baseline IRT model characterizing the ADAS-cog was built based on dat...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer US
2014
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153970/ https://www.ncbi.nlm.nih.gov/pubmed/24595495 http://dx.doi.org/10.1007/s11095-014-1315-5 |