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A Macrohistone Variant Links Dynamic Chromatin Compaction to BRCA1-Dependent Genome Maintenance

Appropriate DNA double-strand break (DSB) repair factor choice is essential for ensuring accurate repair outcome and genomic integrity. The factors that regulate this process remain poorly understood. Here, we identify two repressive chromatin components, the macrohistone variant macroH2A1 and the H...

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Detalles Bibliográficos
Autores principales: Khurana, Simran, Kruhlak, Michael J., Kim, Jeongkyu, Tran, Andy D., Liu, Jinping, Nyswaner, Katherine, Shi, Lei, Jailwala, Parthav, Sung, Myong-Hee, Hakim, Ofir, Oberdoerffer, Philipp
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154351/
https://www.ncbi.nlm.nih.gov/pubmed/25131201
http://dx.doi.org/10.1016/j.celrep.2014.07.024