Molecular Differences and Similarities Between Alzheimer’s Disease and the 5XFAD Transgenic Mouse Model of Amyloidosis

Transgenic (Tg) mouse models of Alzheimer’s disease (AD) have been extensively used to study the pathophysiology of this dementia and to test the efficacy of drugs to treat AD. The 5XFAD Tg mouse, which contains two presenilin-1 and three amyloid precursor protein (APP) mutations, was designed to ra...

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Detalles Bibliográficos
Autores principales: Maarouf, Chera L, Kokjohn, Tyler A, Whiteside, Charisse M, Macias, MiMi P, Kalback, Walter M, Sabbagh, Marwan N, Beach, Thomas G, Vassar, Robert, Roher, Alex E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154482/
https://www.ncbi.nlm.nih.gov/pubmed/25210460
http://dx.doi.org/10.4137/BCI.S13025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154482/
https://www.ncbi.nlm.nih.gov/pubmed/25210460
http://dx.doi.org/10.4137/BCI.S13025

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