Cargando…

Molecular Differences and Similarities Between Alzheimer’s Disease and the 5XFAD Transgenic Mouse Model of Amyloidosis

Transgenic (Tg) mouse models of Alzheimer’s disease (AD) have been extensively used to study the pathophysiology of this dementia and to test the efficacy of drugs to treat AD. The 5XFAD Tg mouse, which contains two presenilin-1 and three amyloid precursor protein (APP) mutations, was designed to ra...

Descripción completa

Detalles Bibliográficos
Autores principales:	Maarouf, Chera L, Kokjohn, Tyler A, Whiteside, Charisse M, Macias, MiMi P, Kalback, Walter M, Sabbagh, Marwan N, Beach, Thomas G, Vassar, Robert, Roher, Alex E
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Libertas Academica 2013
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154482/ https://www.ncbi.nlm.nih.gov/pubmed/25210460 http://dx.doi.org/10.4137/BCI.S13025

Ejemplares similares

Biochemical Assessment of Precuneus and Posterior Cingulate Gyrus in the Context of Brain Aging and Alzheimer’s Disease
por: Maarouf, Chera L., et al.
Publicado: (2014)

Morphological and Pathological Evolution of the Brain Microcirculation in Aging and Alzheimer’s Disease
por: Hunter, Jesse M., et al.
Publicado: (2012)

Bapineuzumab Alters Aβ Composition: Implications for the Amyloid Cascade Hypothesis and Anti-Amyloid Immunotherapy
por: Roher, Alex E., et al.
Publicado: (2013)

The biochemical aftermath of anti-amyloid immunotherapy
por: Maarouf, Chera L, et al.
Publicado: (2010)

Quantitative Appraisal of Ventricular Cerebrospinal Fluid Biomarkers in Neuropathologically Diagnosed Parkinson’s Disease Cases Lacking Alzheimer’s Disease Pathology
por: Maarouf, Chera L., et al.
Publicado: (2013)

Alzheimer's Disease and Non-Demented High Pathology Control Nonagenarians: Comparing and Contrasting the Biochemistry of Cognitively Successful Aging
por: Maarouf, Chera L., et al.
Publicado: (2011)

Cerebral blood flow in Alzheimer’s disease
por: Roher, Alex E, et al.
Publicado: (2012)

Histopathological and molecular heterogeneity among individuals with dementia associated with Presenilin mutations
por: Maarouf, Chera L, et al.
Publicado: (2008)

Reduced clinical and postmortem measures of cardiac pathology in subjects with advanced Alzheimer's Disease
por: Beach, Thomas G, et al.
Publicado: (2011)

ER stress is not elevated in the 5XFAD mouse model of Alzheimer's disease
por: Sadleir, Katherine R., et al.
Publicado: (2018)

Oral nimodipine treatment has no effect on amyloid pathology or neuritic dystrophy in the 5XFAD mouse model of amyloidosis
por: Sadleir, Katherine R., et al.
Publicado: (2022)

Aβ reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP level
por: Sadleir, Katherine R, et al.
Publicado: (2015)

Functional and structural connectome properties in the 5XFAD transgenic mouse model of Alzheimer’s disease
por: Kesler, Shelli R., et al.
Publicado: (2018)

A combination Alzheimer’s therapy targeting BACE1 and neprilysin in 5XFAD transgenic mice
por: Devi, Latha, et al.
Publicado: (2015)

Neuron loss in the 5XFAD mouse model of Alzheimer’s disease correlates with intraneuronal Aβ(42) accumulation and Caspase-3 activation
por: Eimer, William A, et al.
Publicado: (2013)

Impaired hepatic amyloid-beta degradation in Alzheimer’s disease
por: Maarouf, Chera L., et al.
Publicado: (2018)

Quinacrine directly dissociates amyloid plaques in the brain of 5XFAD transgenic mouse model of Alzheimer’s disease
por: Park, Sohui, et al.
Publicado: (2021)

Temporal gene profiling of the 5XFAD transgenic mouse model highlights the importance of microglial activation in Alzheimer’s disease
por: Landel, Véréna, et al.
Publicado: (2014)

A Transgenic 5xFAD-M Line of Mice for Dendritic Spine Morphology Analysis in Alzheimer’s Disease
por: Ilina, Anastasiia, et al.
Publicado: (2023)

Maternal separation differentially modulates early pathology by sex in 5xFAD Alzheimer’s disease-transgenic mice
por: Garcia, M.G., et al.
Publicado: (2023)

Long-Term Administration of Vespa velutina nigrithorax Venom Ameliorates Alzheimer’s Phenotypes in 5xFAD Transgenic Mice
por: Jeong, Yoon Ah, et al.
Publicado: (2023)

Pregabalin Treatment does not Affect Amyloid Pathology in 5XFAD Mice
por: Sadleir, Katherine R., et al.
Publicado: (2021)

TrkB reduction exacerbates Alzheimer's disease-like signaling aberrations and memory deficits without affecting β-amyloidosis in 5XFAD mice
por: Devi, L, et al.
Publicado: (2015)

Fructus mume extracts alleviate cognitive impairments in 5XFAD transgenic mice
por: Park, Jung-Cheol, et al.
Publicado: (2016)

4-Hydroxynonenal Immunoreactivity Is Increased in the Frontal Cortex of 5XFAD Transgenic Mice
por: Shin, Sang-Wook, et al.
Publicado: (2020)

Carprofen alleviates Alzheimer-like phenotypes of 5XFAD transgenic mice by targeting the pathological hallmarks induced by amyloid-β aggregation
por: Lee, Donghee, et al.
Publicado: (2023)

5xFAD mice do not have myenteric amyloidosis, dysregulation of neuromuscular transmission or gastrointestinal dysmotility
por: Yelleswarapu, Narayana Krishna, et al.
Publicado: (2022)

Erratum to: Fructus mume extracts alleviate cognitive impairments in 5XFAD transgenic mice
por: Park, Jung-Cheol, et al.
Publicado: (2016)

Preservation of dendritic spine morphology and postsynaptic signaling markers after treatment with solid lipid curcumin particles in the 5xFAD mouse model of Alzheimer’s amyloidosis
por: Maiti, Panchanan, et al.
Publicado: (2021)

Intravenous Injection of PHF-Tau Proteins From Alzheimer Brain Exacerbates Neuroinflammation, Amyloid Beta, and Tau Pathologies in 5XFAD Transgenic Mice
por: Houben, Sarah, et al.
Publicado: (2020)

Fluorescent indolizine derivative YI-13 detects amyloid-β monomers, dimers, and plaques in the brain of 5XFAD Alzheimer transgenic mouse model
por: Kim, DaWon, et al.
Publicado: (2020)

(-)-Oleocanthal Nutraceuticals for Alzheimer’s Disease Amyloid Pathology: Novel Oral Formulations, Therapeutic, and Molecular Insights in 5xFAD Transgenic Mice Model
por: Tajmim, Afsana, et al.
Publicado: (2021)

Peptide aptamer targeting Aβ–PrP–Fyn axis reduces Alzheimer’s disease pathologies in 5XFAD transgenic mouse model
por: Ali, Tahir, et al.
Publicado: (2023)

Correction to: Preservation of dendritic spine morphology and postsynaptic signaling markers after treatment with solid lipid curcumin particles in the 5xFAD mouse model of Alzheimer’s amyloidosis
por: Maiti, Panchanan, et al.
Publicado: (2022)

Insulin deficiency exacerbates cerebral amyloidosis and behavioral deficits in an Alzheimer transgenic mouse model
por: Wang, Xu, et al.
Publicado: (2010)

Correction: Fluorescent indolizine derivative YI-13 detects amyloid-β monomers, dimers, and plaques in the brain of 5XFAD Alzheimer transgenic mouse model
por: Kim, DaWon, et al.
Publicado: (2021)

Retraction Note: Preservation of dendritic spine morphology and postsynaptic signaling markers after treatment with solid lipid curcumin particles in the 5xFAD mouse model of Alzheimer’s amyloidosis
por: Maiti, Panchanan, et al.
Publicado: (2023)

Phloroglucinol Attenuates the Cognitive Deficits of the 5XFAD Mouse Model of Alzheimer’s Disease
por: Yang, Eun-Jeong, et al.
Publicado: (2015)

Synaptosomal Mitochondrial Dysfunction in 5xFAD Mouse Model of Alzheimer's Disease
por: Wang, Lu, et al.
Publicado: (2016)

Axonal and myelinic pathology in 5xFAD Alzheimer’s mouse spinal cord
por: Chu, Tak-Ho, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_j01dt411milj3hkui9cj15uj98