Data-Derived Modeling Characterizes Plasticity of MAPK Signaling in Melanoma

The majority of melanomas have been shown to harbor somatic mutations in the RAS-RAF-MEK-MAPK and PI3K-AKT pathways, which play a major role in regulation of proliferation and survival. The prevalence of these mutations makes these kinase signal transduction pathways an attractive target for cancer...

Descripción completa

Detalles Bibliográficos
Autores principales: Bernardo-Faura, Marti, Massen, Stefan, Falk, Christine S., Brady, Nathan R., Eils, Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154640/
https://www.ncbi.nlm.nih.gov/pubmed/25188314
http://dx.doi.org/10.1371/journal.pcbi.1003795

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154640/
https://www.ncbi.nlm.nih.gov/pubmed/25188314
http://dx.doi.org/10.1371/journal.pcbi.1003795

Ejemplares similares