Bipartite Recognition of DNA by TCF/Pangolin Is Remarkably Flexible and Contributes to Transcriptional Responsiveness and Tissue Specificity of Wingless Signaling

The T-cell factor (TCF) family of transcription factors are major mediators of Wnt/β-catenin signaling in metazoans. All TCFs contain a High Mobility Group (HMG) domain that possesses specific DNA binding activity. In addition, many TCFs contain a second DNA binding domain, the C-clamp, which binds...

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Detalles Bibliográficos
Autores principales: Archbold, Hilary C., Broussard, Chris, Chang, Mikyung V., Cadigan, Ken M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154663/
https://www.ncbi.nlm.nih.gov/pubmed/25188465
http://dx.doi.org/10.1371/journal.pgen.1004591

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154663/
https://www.ncbi.nlm.nih.gov/pubmed/25188465
http://dx.doi.org/10.1371/journal.pgen.1004591

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