Role of the DNA Base Excision Repair Protein, APE1 in Cisplatin, Oxaliplatin, or Carboplatin Induced Sensory Neuropathy

Although chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting side effect of platinum drugs, the mechanisms of this toxicity remain unknown. Previous work in our laboratory suggests that cisplatin-induced CIPN is secondary to DNA damage which is susceptible to base excision repair (B...

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Detalles Bibliográficos
Autores principales: Kelley, Mark R., Jiang, Yanlin, Guo, Chunlu, Reed, April, Meng, Hongdi, Vasko, Michael R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154694/
https://www.ncbi.nlm.nih.gov/pubmed/25188410
http://dx.doi.org/10.1371/journal.pone.0106485

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154694/
https://www.ncbi.nlm.nih.gov/pubmed/25188410
http://dx.doi.org/10.1371/journal.pone.0106485

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