Structural Insight into Tau Protein’s Paradox of Intrinsically Disordered Behavior, Self-Acetylation Activity, and Aggregation

[Image: see text] Tau is an intrinsically disordered protein (IDP) implicated in Alzheimer’s disease. Recently, tau proteins were discovered to be able to catalyze self-acetylation, which may promote its pathological aggregation. Understanding the paradox of tau’s random-like conformations, aggregat...

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Detalles Bibliográficos
Autores principales: Luo, Yin, Ma, Buyong, Nussinov, Ruth, Wei, Guanghong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154703/
https://www.ncbi.nlm.nih.gov/pubmed/25206938
http://dx.doi.org/10.1021/jz501457f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154703/
https://www.ncbi.nlm.nih.gov/pubmed/25206938
http://dx.doi.org/10.1021/jz501457f

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