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Structural Insight into Tau Protein’s Paradox of Intrinsically Disordered Behavior, Self-Acetylation Activity, and Aggregation
[Image: see text] Tau is an intrinsically disordered protein (IDP) implicated in Alzheimer’s disease. Recently, tau proteins were discovered to be able to catalyze self-acetylation, which may promote its pathological aggregation. Understanding the paradox of tau’s random-like conformations, aggregat...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154703/ https://www.ncbi.nlm.nih.gov/pubmed/25206938 http://dx.doi.org/10.1021/jz501457f |