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Quantification of Protein Copy Number in Yeast: The NAD(+) Metabolome

Saccharomyces cerevisiae is calorie-restricted by lowering glucose from 2% to 0.5%. Under low glucose conditions, replicative lifespan is extended in a manner that depends on the NAD(+)-dependent protein lysine deacetylase Sir2 and NAD(+) salvage enzymes. Because NAD(+) is required for glucose utili...

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Detalles Bibliográficos
Autores principales: Mei, Szu-Chieh, Brenner, Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154715/
https://www.ncbi.nlm.nih.gov/pubmed/25188219
http://dx.doi.org/10.1371/journal.pone.0106496