Mouse, but Not Human, ApoB-100 Lipoprotein Cholesterol Is a Potent Innate Inhibitor of Streptococcus pneumoniae Pneumolysin

Streptococcus pneumoniae produces the pore-forming toxin pneumolysin (PLY), which is a member of the cholesterol-dependent cytolysin (CDC) family of toxins. The CDCs recognize and bind the 3β-hydroxyl group of cholesterol at the cell surface, which initiates membrane pore formation. The cholesterol...

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Detalles Bibliográficos
Autores principales: Wade, Kristin R., Hotze, Eileen M., Briles, David E., Tweten, Rodney K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154877/
https://www.ncbi.nlm.nih.gov/pubmed/25188225
http://dx.doi.org/10.1371/journal.ppat.1004353

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154877/
https://www.ncbi.nlm.nih.gov/pubmed/25188225
http://dx.doi.org/10.1371/journal.ppat.1004353

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