Global Nav1.7 Knockout Mice Recapitulate the Phenotype of Human Congenital Indifference to Pain

Clinical genetic studies have shown that loss of Nav1.7 function leads to the complete loss of acute pain perception. The global deletion is reported lethal in mice, however, and studies of mice with promoter-specific deletions of Nav1.7 have suggested that the role of Nav1.7 in pain transduction de...

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Detalles Bibliográficos
Autores principales: Gingras, Jacinthe, Smith, Sarah, Matson, David J., Johnson, Danielle, Nye, Kim, Couture, Lauren, Feric, Elma, Yin, Ruoyuan, Moyer, Bryan D., Peterson, Matthew L., Rottman, James B., Beiler, Rudolph J., Malmberg, Annika B., McDonough, Stefan I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154897/
https://www.ncbi.nlm.nih.gov/pubmed/25188265
http://dx.doi.org/10.1371/journal.pone.0105895

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154897/
https://www.ncbi.nlm.nih.gov/pubmed/25188265
http://dx.doi.org/10.1371/journal.pone.0105895

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