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Loss of cilia causes embryonic lung hypoplasia, liver fibrosis, and cholestasis in the talpid(3) ciliopathy mutant
Sonic hedgehog plays an essential role in maintaining hepatoblasts in a proliferative non-differentiating state during embryogenesis. Transduction of the Hedgehog signaling pathway is dependent on the presence of functional primary cilia and hepatoblasts, therefore, must require primary cilia for no...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Landes Bioscience
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154951/ https://www.ncbi.nlm.nih.gov/pubmed/24743779 http://dx.doi.org/10.4161/org.28819 |