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Threonyl-tRNA synthetase overexpression correlates with angiogenic markers and progression of human ovarian cancer

BACKGROUND: Ovarian tumors create a dynamic microenvironment that promotes angiogenesis and reduces immune responses. Our research has revealed that threonyl-tRNA synthetase (TARS) has an extracellular angiogenic activity separate from its function in protein synthesis. The objective of this study w...

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Detalles Bibliográficos
Autores principales: Wellman, Theresa L, Eckenstein, Midori, Wong, Cheung, Rincon, Mercedes, Ashikaga, Takamaru, Mount, Sharon L, Francklyn, Christopher S, Lounsbury, Karen M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155084/
https://www.ncbi.nlm.nih.gov/pubmed/25163878
http://dx.doi.org/10.1186/1471-2407-14-620