Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles

Clozapine is a particularly effective antipsychotic medication but its use is curtailed by the risk of clozapine-induced agranulocytosis/granulocytopenia (CIAG), a severe adverse drug reaction occurring in up to 1% of treated individuals. Identifying genetic risk factors for CIAG could enable safer...

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Detalles Bibliográficos
Autores principales: Goldstein, Jacqueline I, Jarskog, L Fredrik, Hilliard, Chris, Alfirevic, Ana, Duncan, Laramie, Fourches, Denis, Huang, Hailiang, Lek, Monkol, Neale, Benjamin M, Ripke, Stephan, Shianna, Kevin, Szatkiewicz, Jin P, Tropsha, Alexander, van den Oord, Edwin JCG, Cascorbi, Ingolf, Dettling, Michael, Gazit, Ephraim, Goff, Donald C, Holden, Arthur L, Kelly, Deanna L, Malhotra, Anil K, Nielsen, Jimmi, Pirmohamed, Munir, Rujescu, Dan, Werge, Thomas, Levy, Deborah L, Josiassen, Richard C, Kennedy, James L, Lieberman, Jeffrey A, Daly, Mark J, Sullivan, Patrick F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155508/
https://www.ncbi.nlm.nih.gov/pubmed/25187353
http://dx.doi.org/10.1038/ncomms5757

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155508/
https://www.ncbi.nlm.nih.gov/pubmed/25187353
http://dx.doi.org/10.1038/ncomms5757

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