Timosaponin A3 induces hepatotoxicity in rats through inducing oxidative stress and down-regulating bile acid transporters

AIM: To investigate the mechanisms underlying the hepatotoxicity of timosaponin A3 (TA3), a steroidal saponin from Anemarrhena asphodeloides, in rats. METHODS: Male SD rats were administered TA3 (100 mg·kg(−1)·d(−1), po) for 14 d, and the blood and bile samples were collected after the final adminis...

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Detalles Bibliográficos
Autores principales: Wu, Zhi-tao, Qi, Xin-ming, Sheng, Jing-jing, Ma, Lei-lei, Ni, Xuan, Ren, Jin, Huang, Cheng-gang, Pan, Guo-yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155534/
https://www.ncbi.nlm.nih.gov/pubmed/25087997
http://dx.doi.org/10.1038/aps.2014.65

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155534/
https://www.ncbi.nlm.nih.gov/pubmed/25087997
http://dx.doi.org/10.1038/aps.2014.65

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