Mapping the Putative G Protein-coupled Receptor (GPCR) Docking Site on GPCR Kinase 2: INSIGHTS FROM INTACT CELL PHOSPHORYLATION AND RECRUITMENT ASSAYS

G protein-coupled receptor kinases (GRKs) phosphorylate agonist-occupied receptors initiating the processes of desensitization and β-arrestin-dependent signaling. Interaction of GRKs with activated receptors serves to stimulate their kinase activity. The extreme N-terminal helix (αN), the kinase sma...

Descripción completa

Detalles Bibliográficos
Autores principales: Beautrait, Alexandre, Michalski, Kevin R., Lopez, Thomas S., Mannix, Katelynn M., McDonald, Devin J., Cutter, Amber R., Medina, Christopher B., Hebert, Aaron M., Francis, Charnelle J., Bouvier, Michel, Tesmer, John J. G., Sterne-Marr, Rachel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Signal Transduction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155688/
https://www.ncbi.nlm.nih.gov/pubmed/25049229
http://dx.doi.org/10.1074/jbc.M114.593178

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155688/
https://www.ncbi.nlm.nih.gov/pubmed/25049229
http://dx.doi.org/10.1074/jbc.M114.593178

Ejemplares similares