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Mapping the Putative G Protein-coupled Receptor (GPCR) Docking Site on GPCR Kinase 2: INSIGHTS FROM INTACT CELL PHOSPHORYLATION AND RECRUITMENT ASSAYS

G protein-coupled receptor kinases (GRKs) phosphorylate agonist-occupied receptors initiating the processes of desensitization and β-arrestin-dependent signaling. Interaction of GRKs with activated receptors serves to stimulate their kinase activity. The extreme N-terminal helix (αN), the kinase sma...

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Detalles Bibliográficos
Autores principales:	Beautrait, Alexandre, Michalski, Kevin R., Lopez, Thomas S., Mannix, Katelynn M., McDonald, Devin J., Cutter, Amber R., Medina, Christopher B., Hebert, Aaron M., Francis, Charnelle J., Bouvier, Michel, Tesmer, John J. G., Sterne-Marr, Rachel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2014
Materias:	Signal Transduction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155688/ https://www.ncbi.nlm.nih.gov/pubmed/25049229 http://dx.doi.org/10.1074/jbc.M114.593178

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