Viral vector-mediated downregulation of RhoA increases survival and axonal regeneration of retinal ganglion cells

The Rho/ROCK pathway is a promising therapeutic target in neurodegenerative and neurotraumatic diseases. Pharmacological inhibition of various pathway members has been shown to promote neuronal regeneration and survival. However, because pharmacological inhibitors are inherently limited in their spe...

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Detalles Bibliográficos
Autores principales: Koch, Jan Christoph, Tönges, Lars, Michel, Uwe, Bähr, Mathias, Lingor, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155783/
https://www.ncbi.nlm.nih.gov/pubmed/25249936
http://dx.doi.org/10.3389/fncel.2014.00273

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155783/
https://www.ncbi.nlm.nih.gov/pubmed/25249936
http://dx.doi.org/10.3389/fncel.2014.00273

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