Impact of stearic acid and oleic acid on hemostatic factors in the context of controlled diets consumed by healthy men

The effects of stearic acid (STA) on cardiovascular disease risk beyond lipid and lipoprotein risk factors, including hemostasis, are unclear, particularly when compared with unsaturated fatty acids. The aim of the present study is to compare the effects of STA with those of oleic acid (OL) on marke...

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Autores principales: Gebauer, S K, Tracy, R P, Baer, D J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155798/
https://www.ncbi.nlm.nih.gov/pubmed/24736679
http://dx.doi.org/10.1038/ejcn.2014.62
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author Gebauer, S K
Tracy, R P
Baer, D J
author_facet Gebauer, S K
Tracy, R P
Baer, D J
author_sort Gebauer, S K
collection PubMed
description The effects of stearic acid (STA) on cardiovascular disease risk beyond lipid and lipoprotein risk factors, including hemostasis, are unclear, particularly when compared with unsaturated fatty acids. The aim of the present study is to compare the effects of STA with those of oleic acid (OL) on markers of hemostasis. In a randomized crossover study, 50 men consumed six controlled diets for 5 weeks each (39% energy from fat, 15% energy from protein, 46% energy from carbohydrate (CHO)). Fat (8% energy) was replaced across diets by: STA, OL, CHO (control), trans fatty acids (TFAs), TFA/STA and 12:0–16:0 saturated fatty acids. Factor VIIc, plasminogen activator inhibitor-1 (PAI-1) and plasmin alpha-2-antiplasmin complex concentrations were not different between OL and STA (P>0.05). Compared with control, OL increased factor VIIc and PAI-1 (P⩽0.05), whereas there were no differences with STA (P>0.05). STA and OL similarly affect markers of hemostasis in healthy men, within the context of a highly controlled diet.
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spelling pubmed-41557982014-09-10 Impact of stearic acid and oleic acid on hemostatic factors in the context of controlled diets consumed by healthy men Gebauer, S K Tracy, R P Baer, D J Eur J Clin Nutr Short Communication The effects of stearic acid (STA) on cardiovascular disease risk beyond lipid and lipoprotein risk factors, including hemostasis, are unclear, particularly when compared with unsaturated fatty acids. The aim of the present study is to compare the effects of STA with those of oleic acid (OL) on markers of hemostasis. In a randomized crossover study, 50 men consumed six controlled diets for 5 weeks each (39% energy from fat, 15% energy from protein, 46% energy from carbohydrate (CHO)). Fat (8% energy) was replaced across diets by: STA, OL, CHO (control), trans fatty acids (TFAs), TFA/STA and 12:0–16:0 saturated fatty acids. Factor VIIc, plasminogen activator inhibitor-1 (PAI-1) and plasmin alpha-2-antiplasmin complex concentrations were not different between OL and STA (P>0.05). Compared with control, OL increased factor VIIc and PAI-1 (P⩽0.05), whereas there were no differences with STA (P>0.05). STA and OL similarly affect markers of hemostasis in healthy men, within the context of a highly controlled diet. Nature Publishing Group 2014-09 2014-04-16 /pmc/articles/PMC4155798/ /pubmed/24736679 http://dx.doi.org/10.1038/ejcn.2014.62 Text en Copyright © 2014 Macmillan Publishers Limited http://creativecommons.org/licenses/by/3.0/ This work is licensed under a Creative Commons Attribution 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/
spellingShingle Short Communication
Gebauer, S K
Tracy, R P
Baer, D J
Impact of stearic acid and oleic acid on hemostatic factors in the context of controlled diets consumed by healthy men
title Impact of stearic acid and oleic acid on hemostatic factors in the context of controlled diets consumed by healthy men
title_full Impact of stearic acid and oleic acid on hemostatic factors in the context of controlled diets consumed by healthy men
title_fullStr Impact of stearic acid and oleic acid on hemostatic factors in the context of controlled diets consumed by healthy men
title_full_unstemmed Impact of stearic acid and oleic acid on hemostatic factors in the context of controlled diets consumed by healthy men
title_short Impact of stearic acid and oleic acid on hemostatic factors in the context of controlled diets consumed by healthy men
title_sort impact of stearic acid and oleic acid on hemostatic factors in the context of controlled diets consumed by healthy men
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155798/
https://www.ncbi.nlm.nih.gov/pubmed/24736679
http://dx.doi.org/10.1038/ejcn.2014.62
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