Light-mediated in cell downregulation of G-quadruplex-containing genes using a photo-caged ligand

The use of a caged G-quadruplex ligand allows for transcriptional control of quadruplex-containing genes using UV light as an external trigger. An important oncogene, SRC, involved in the initiation and proliferation of epithelial tumours is shown to be significantly downregulated in cells treated b...

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Detalles Bibliográficos
Autores principales: Murat, Pierre, Gormally, Michael V., Sanders, Debbie, Antonio, Marco Di, Balasubramanian, Shankar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2013
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155816/
https://www.ncbi.nlm.nih.gov/pubmed/23949446
http://dx.doi.org/10.1039/c3cc44737e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155816/
https://www.ncbi.nlm.nih.gov/pubmed/23949446
http://dx.doi.org/10.1039/c3cc44737e

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