Light-mediated in cell downregulation of G-quadruplex-containing genes using a photo-caged ligand

The use of a caged G-quadruplex ligand allows for transcriptional control of quadruplex-containing genes using UV light as an external trigger. An important oncogene, SRC, involved in the initiation and proliferation of epithelial tumours is shown to be significantly downregulated in cells treated b...

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Autores principales: Murat, Pierre, Gormally, Michael V., Sanders, Debbie, Antonio, Marco Di, Balasubramanian, Shankar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2013
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155816/
https://www.ncbi.nlm.nih.gov/pubmed/23949446
http://dx.doi.org/10.1039/c3cc44737e
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author Murat, Pierre
Gormally, Michael V.
Sanders, Debbie
Antonio, Marco Di
Balasubramanian, Shankar
author_facet Murat, Pierre
Gormally, Michael V.
Sanders, Debbie
Antonio, Marco Di
Balasubramanian, Shankar
author_sort Murat, Pierre
collection PubMed
description The use of a caged G-quadruplex ligand allows for transcriptional control of quadruplex-containing genes using UV light as an external trigger. An important oncogene, SRC, involved in the initiation and proliferation of epithelial tumours is shown to be significantly downregulated in cells treated by the caged ligand in synergy with UV light treatment.
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spelling pubmed-41558162014-09-08 Light-mediated in cell downregulation of G-quadruplex-containing genes using a photo-caged ligand Murat, Pierre Gormally, Michael V. Sanders, Debbie Antonio, Marco Di Balasubramanian, Shankar Chem Commun (Camb) Chemistry The use of a caged G-quadruplex ligand allows for transcriptional control of quadruplex-containing genes using UV light as an external trigger. An important oncogene, SRC, involved in the initiation and proliferation of epithelial tumours is shown to be significantly downregulated in cells treated by the caged ligand in synergy with UV light treatment. Royal Society of Chemistry 2013-10-04 2013-08-15 /pmc/articles/PMC4155816/ /pubmed/23949446 http://dx.doi.org/10.1039/c3cc44737e Text en This journal is © The Royal Society of Chemistry 2013 http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Chemistry
Murat, Pierre
Gormally, Michael V.
Sanders, Debbie
Antonio, Marco Di
Balasubramanian, Shankar
Light-mediated in cell downregulation of G-quadruplex-containing genes using a photo-caged ligand
title Light-mediated in cell downregulation of G-quadruplex-containing genes using a photo-caged ligand
title_full Light-mediated in cell downregulation of G-quadruplex-containing genes using a photo-caged ligand
title_fullStr Light-mediated in cell downregulation of G-quadruplex-containing genes using a photo-caged ligand
title_full_unstemmed Light-mediated in cell downregulation of G-quadruplex-containing genes using a photo-caged ligand
title_short Light-mediated in cell downregulation of G-quadruplex-containing genes using a photo-caged ligand
title_sort light-mediated in cell downregulation of g-quadruplex-containing genes using a photo-caged ligand
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155816/
https://www.ncbi.nlm.nih.gov/pubmed/23949446
http://dx.doi.org/10.1039/c3cc44737e
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