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Light-mediated in cell downregulation of G-quadruplex-containing genes using a photo-caged ligand
The use of a caged G-quadruplex ligand allows for transcriptional control of quadruplex-containing genes using UV light as an external trigger. An important oncogene, SRC, involved in the initiation and proliferation of epithelial tumours is shown to be significantly downregulated in cells treated b...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155816/ https://www.ncbi.nlm.nih.gov/pubmed/23949446 http://dx.doi.org/10.1039/c3cc44737e |