Altered trafficking of mutated growth factor receptors and their associated molecules: implication for human cancers

Ligand-stimulated receptor tyrosine kinases (RTKs) are phosphorylated/ubiquitinated, endocytosed and transported to the lysosomes via endosomes/multivesicular bodies, resulting in the attenuation of signal transmission. If this physiological mechanism of RTK signal downregulation is perturbed, signa...

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Detalles Bibliográficos
Autores principales: Kon, Shunsuke, Kobayashi, Nobuhide, Satake, Masanobu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Mini Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156482/
https://www.ncbi.nlm.nih.gov/pubmed/25210647
http://dx.doi.org/10.4161/cl.28461

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156482/
https://www.ncbi.nlm.nih.gov/pubmed/25210647
http://dx.doi.org/10.4161/cl.28461

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