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Altered trafficking of mutated growth factor receptors and their associated molecules: implication for human cancers
Ligand-stimulated receptor tyrosine kinases (RTKs) are phosphorylated/ubiquitinated, endocytosed and transported to the lysosomes via endosomes/multivesicular bodies, resulting in the attenuation of signal transmission. If this physiological mechanism of RTK signal downregulation is perturbed, signa...
Autores principales: | Kon, Shunsuke, Kobayashi, Nobuhide, Satake, Masanobu |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Landes Bioscience
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156482/ https://www.ncbi.nlm.nih.gov/pubmed/25210647 http://dx.doi.org/10.4161/cl.28461 |
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